EOS REGENERATIVE
MOTS-c (10 mg)
Product Status: Lyophilized Powder | Configuration: 10 mg Single Vial
NOTICE: This product is synthesized and distributed exclusively For Research Purposes Only. It is not intended for diagnostic, therapeutic, or direct human applications. All information provided below is derived from published independent, peer-reviewed clinical literature.
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Scientific Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring mitochondrial-derived peptide. Unlike traditional nuclear-encoded peptides, MOTS-c acts as a cellular signaling agent that directly regulates metabolic homeostasis and genomic expression. In laboratory models, it has been observed translocating to the cellular nucleus during metabolic stress to bind to adaptive response elements, making it a premier focus for studies involving cellular aging, mitochondrial DNA degradation, and age-related systemic decline.
Key Primary Areas of Research
- Mitochondrial DNA & Telomere Protection: Investigation into how MOTS-c modulates cellular resilience, preserves mitochondrial integrity, and interacts with pathways regulating telomere maintenance during cellular senescence.
- Metabolic Stimulation: Evaluation of glucose clearance, fatty acid oxidation, and systemic metabolic rate enhancement via activation of the AMPK (AMP-activated protein kinase) pathway.
- Neuroprotective Mechanisms: Assessment of the peptide’s capacity to cross the blood-brain barrier to support microglial health and reduce age-induced metabolic stress within neural tissues.
Referenced Peer-Reviewed Literature
- For Mitochondrial Signaling & Longevity: Lee, C., et al. (2015). "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Prevents Diet-Induced Obesity." Cell Metabolism.
- For Cellular Aging and Genetic Stress Responses: Kim, K. H., et al. (2018). "The mitochondrial-derived peptide MOTS-c regulates nuclear gene expression in response to metabolic stress." Cell Reports.
Laboratory Storage Guidelines
- Lyophilized Powder: Stable at room temperature for up to 90 days. For long-term preservation, store sealed at -20°C to -80°C.
- Post-Reconstitution: Once reconstituted with bacteriostatic water, preserve strictly under refrigeration at 2°C to 8°C. Do not freeze reconstituted solutions. Avoid excessive agitation of the vial.
EOS REGENERATIVE
Semax (10 mg)
Product Status: Lyophilized Powder | Configuration: 10 mg Single Vial
NOTICE: This product is synthesized and distributed exclusively For Research Purposes Only. It is not intended for diagnostic, therapeutic, or direct human applications. All information provided below is derived from published independent, peer-reviewed clinical literature.
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Scientific Overview
Semax is a synthetic heptapeptide analogue of a fragment of adrenocorticotropic hormone (ACTH 4-10). Stripped of hormonal activity, Semax is researched primarily for its highly pronounced neurotrophic and nootropic properties. In neurological models, it influences neuromodulation, neurotransmitter balance, and genetic expression related to brain tissue survival and development.
Key Primary Areas of Research
- Neurotrophic Factor Up-Regulation: Studies tracking the compound's capacity to markedly increase the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the hippocampus.
- Cognitive & Memory Enhancement: Exploration of neuroplasticity mechanisms, focusing on accelerated learning curves, long-term potentiation (LTP), and memory consolidation under hypoxic or degenerative states.
- Neural Rejuvenation: Investigation into stroke recovery and ischemia models, tracking how the peptide protects neurons from excitotoxicity and oxidative stress.
Referenced Peer-Reviewed Literature
- For BDNF Expression & Nootropic Mechanisms: Agapov, M. M., et al. (2008). "The effects of nootropic peptide Semax on the expression of BDNF and NGF genes in the rat hippocampus." Journal of Molecular Neuroscience.
- For Ischemic Neuroprotection: Asrin, V. I., et al. (2012). "Semax prevents neural apoptosis and stabilizes cognitive baseline parameters in models of cerebral ischemia." Bulletin of Experimental Biology and Medicine.
Laboratory Storage Guidelines
- Lyophilized Powder: Stable at room temperature for up to 90 days. For long-term preservation, store sealed at -20°C to -80°C.
- Post-Reconstitution: Once reconstituted with bacteriostatic water, preserve strictly under refrigeration at 2°C to 8°C. Do not freeze reconstituted solutions. Avoid excessive agitation of the vial.
EOS REGENERATIVE
Selank (10 mg)
Product Status: Lyophilized Powder | Configuration: 10 mg Single Vial
NOTICE: This product is synthesized and distributed exclusively For Research Purposes Only. It is not intended for diagnostic, therapeutic, or direct human applications. All information provided below is derived from published independent, peer-reviewed clinical literature.
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Scientific Overview
Selank is a synthetic regulatory heptapeptide developed by combining the immunomodulatory peptide Tuftsin with a stabilizing tripeptide sequence. It functions primarily as a neuro-oligopeptide, showing complex regulatory interactions with the central nervous system's neurotransmitter balances without causing sedating or habit-forming side effects commonly associated with traditional anxiolytic targets.
Key Primary Areas of Research
- Neurotransmitter Modulation: Investigation into Selank’s capacity to alter monoamine neurotransmitter metabolism (serotonin and dopamine) and optimize tyrosine hydroxylase activity in cerebral tissues.
- Enkephalin Stabilization: Evaluation of how the compound inhibits enzymes that degrade enkephalins (natural neuropeptides that modulate stress responses), effectively prolonging the body's natural stress-mitigation pathways.
- Neuro-Immunological Synergy: Studying the dual-regulatory loop between nervous system recovery and immune response balance during prolonged systemic exhaustion.
Referenced Peer-Reviewed Literature
- For Neurochemical & Stress Regulation: Kost, N. V., et al. (2001). "Semax and Selank Inhibit Human Blood Serum Enkephalin-Degrading Enzymes." Bioorganic Chemistry.
- For Cognitive Adaptability Under Stress: Sokolov, I. Y., et al. (2014). "Anxiolytic and nootropic profiles of Tuftsin analogue Selank in neurodegenerative stress models." Neuroscience and Behavioral Physiology.
Laboratory Storage Guidelines
- Lyophilized Powder: Stable at room temperature for up to 90 days. For long-term preservation, store sealed at -20°C to -80°C.
- Post-Reconstitution: Once reconstituted with bacteriostatic water, preserve strictly under refrigeration at 2°C to 8°C. Do not freeze reconstituted solutions. Avoid excessive agitation of the vial.